منابع مشابه
Controlled self assembly of collagen nanoparticle
In recent years carrier-mediated drug delivery has emerged as a powerful methodology for the treatment of various pathologies. The therapeutic index of traditional and novel drugs is enhanced via the increase of specificity due to targeting of drugs to a particular tissue, cell or intracellular compartment, the control over release kinetics, the protection of the active agent, or a combination ...
متن کاملSelf-assembly of synthetic collagen triple helices.
Collagen is the most abundant protein in animals and the major component of connective tissues. Although collagen isolated from natural sources has long served as the basis for some biomaterials, natural collagen is difficult to modify and can engender pathogenic and immunological side effects. Collagen comprises a helix of three strands. Triple helices derived from synthetic peptides are much ...
متن کاملSelf-assembly of collagen on flat surfaces: the interplay of collagen-collagen and collagen-substrate interactions.
Fibrillar collagens, common tissue scaffolds in live organisms, can also self-assemble in vitro from solution. While previous in vitro studies showed that the pH and the electrolyte concentration in solution largely control the collagen assembly, the physical reasons why such control could be exerted are still elusive. To address this issue and to be able to simulate self-assembly over large sp...
متن کاملAn in situ study of collagen self-assembly processes.
We present in situ studies on the self-assembly and dynamic evolution of collagen gels from semidilute solutions in a microfluidic device. Collagen fibrils not only reinforce the mechanical properties of bone and tissues, but they also influence cellular motility and morphology. We access the initial steps of the hierarchical self-assembly of collagen fibrils and networks by using hydrodynamic ...
متن کاملCollagen self-assembly and the development of tendon mechanical properties.
The development of the musculoskeleton and the ability to locomote requires controlled cell division as well as spatial control over deposition of extracellular matrix. Self-assembly of procollagen and its final processing into collagen fibrils occurs extracellularly. The formation of crosslinked collagen fibers results in the conversion of weak liquid-like embryonic tissues to tough elastic so...
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ژورنال
عنوان ژورنال: Journal of Supramolecular Structure
سال: 1974
ISSN: 0091-7419,1547-9366
DOI: 10.1002/jss.400020204